منابع مشابه
FA iPS: correction or reprogramming first?
Fanconi anemia is a genetic disorder caused by loss of function of any of 14 genes in the FA pathway, a pathway coordinating cellular DNA damage repair mechanisms particularly involved in protection from DNA cross-linking agents.2 Clinically, FA manifests with bone marrow failure and increased propensity to malignancy. Genetic complementation of the FA pathway has been shown to correct the hema...
متن کاملGeneration of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming
During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or repair of damaged tissue. The pluripotent stem cells can be derived from inner ...
متن کاملReprogramming Therapeutics: iPS Cell Prospects for Neurodegenerative Disease
The recent description of somatic cell reprogramming to an embryonic stem (ES) cell-like phenotype, termed induced pluripotent stem (iPS) cell technology, presents an exciting potential venue toward cell-based therapeutics and disease models for neurodegenerative disorders. Two recent studies (Dimos et al. and Ebert et al.) describe the initial characterization of neurodegenerative disease pati...
متن کاملCell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering
The procurement of induced pluripotent stem cells, or IPS cells, from adult differentiated animal cells has the potential to revolutionize future medicine, where reprogrammed IPS cells may be used to repair disease-affected tissues on demand. The potential of IPS cell technology is tremendous, but it will be essential to improve the methodologies for IPS cell generation and to precisely evaluat...
متن کاملA Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells
Factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is inefficient, complicating mechanistic studies. Here, we examined defined intermediate cell populations poised to becoming iPSCs by genome-wide analyses. We show that induced pluripotency elicits two transcriptional waves, which are driven by c-Myc/Klf4 (first wave) and Oct4/Sox2/Klf4 (second wave). Cell...
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ژورنال
عنوان ژورنال: Blood
سال: 2012
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2012-04-417246